Fmoc-Dap(Cbz)-OH CAS 204316-36-9 HPLC 99+ Dap Series

1. Peptide Synthesis

• Fmoc-Dap(Cbz)-OH is an Fmoc-protected derivative of 2,3-diaminopropionic acid (Dap).

• The α-amino group is protected with Fmoc, and the β-amino group with Cbz, allowing orthogonal protection in Fmoc solid-phase peptide synthesis (SPPS).

• Enables selective deprotection and coupling steps for complex peptide architectures.

2. Branched and Cyclic Peptide Construction

• Widely used to prepare branched, cyclic, or side-chain-modified peptides.

• The β-amino group (protected by Cbz) allows secondary attachment sites for conjugation or cyclization after selective deprotection.

• Useful in multivalent peptide ligands, peptide dendrimers, and bioconjugates.

3. Functional Peptide Design

• Dap provides a shorter side chain than Dab or Lys, which influences charge distribution and spatial orientation in peptides.

• Common in antimicrobial peptides, enzyme inhibitors, and cell-penetrating peptides where fine-tuning of positive charge and hydrophilicity is needed.

4. Biomedical and Research Use

• Employed in designing drug delivery peptides, linkers, and crosslinkable amino acids for peptide–protein conjugation studies.

• Serves as a model compound for exploring structure–activity relationships in peptide modification.