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Fmoc-β-Ala-Ile-OH Impurities Standards For Peptide Building Blocks
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제품 상세 정보:
결제 및 배송 조건:
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상세 제품 설명
| 제품명: | Fmoc-β-Ala-Ile-OH | CAS 번호: | 해당 없음 |
|---|---|---|---|
| MW: | 353.46 | 모습: | 백색분말 |
| HPLC: | 99% | 저장: | 실온 |
Fmoc-β-Ala-Ile-OH Impurities Standards For Peptide Building Blocks
High-purity Fmoc-β-Ala-Ile-OH for Impurity Research and peptide development.
| Name | Fmoc-β-Ala-Ile-OH |
|---|---|
| CAS NO | NA |
| Molecular Weight | 353.46 |
| Appearance | White Powder |
| HPLC Purity | 99%+ |
| Synonyms | Fmoc-beta-Ala-Ile-OH |
Key Applications
1. Solid-Phase Peptide Synthesis (SPPS)
- Used as a dipeptide building block in peptide synthesis
- Fully compatible with the Fmoc strategy
- The β-alanine unit:
- Introduces flexibility
- Reduces steric hindrance
- The isoleucine residue (Ile):
- Is bulky and hydrophobic
- Can make coupling more challenging → this dipeptide helps improve efficiency
2. Peptide Drug Design
- β-Ala acts as a flexible spacer
- Ile provides strong hydrophobic interaction
Used for:
- Enhancing binding affinity (especially hydrophobic pockets)
- Modulating peptide conformation
- Improving metabolic stability
3. Linker / Spacer Applications
- Acts as a flexible yet hydrophobic linker
- Common in:
- Peptide conjugates
- Drug delivery systems
- Modified therapeutic peptides
Compared to Glycine-based linkers, it is:
- Longer (β-Ala)
- More hydrophobic (Ile)
4. Structure & Conformation Control
- β-Ala disrupts regular secondary structures
- Ile tends to promote hydrophobic packing
Applications:
- Fine-tuning peptide folding
- Designing protease-resistant sequences
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